Biology runs continuously.
Your experiments should too.
Keystone™ is a benchtop system for multi-day cell biology — integrating culture, interventions, and imaging in one uninterrupted run.
Your protocol is only as good as your worst handoff.
Every transfer introduces a variable. Every overnight gap is an uncontrolled condition. Multi-day biology is compromised not by the science, but by the infrastructure around it.
The result is data you can't trust, failures you can't attribute, and runs you have to repeat.
The learning loop doesn't break in the model. It breaks in execution — the layer we're building.
Built for the biology —
not retrofitted to it.
Organoids and spheroids only make sense observed continuously,
not reconstructed from scattered endpoints.
Keystone was built for that from the first frame.
WHAT CONTINUOUS BIOLOGY REQUIRES
Stable culture
The environment drifts the moment cells leave the incubator, and re-equilibration takes time cells don't have. In Keystone™, the run never leaves.
Scheduled actions
Media exchange, dosing, and staining — automatically, at defined timepoints, recorded to the run.
Multimodal readout
Looking intact is not the same as being functional. Brightfield reveals morphology, fluorescence captures phenotypic change, absorbance verifies metabolic activity — read together, on one timeline.
The product is the run.
Keystone™ supports protocols where continuity is essential.
Where a gap in execution becomes a gap in the answer.
Longitudinal phenotyping
The same well across days. No plate movement, no re-equilibration, no gap in the record.
Multi-step assay execution
Every intervention timestamped, logged, attributed to the run. Not an assumption — a record.
Drug response kinetics
Cytostatic and cytotoxic responses look identical at 72 hours. Continuous imaging resolves the kinetic difference - when the arrest began, how far it progressed, whether it recovered.
One run. One record.
Every Keystone™ run produces a traceable record: images, interventions, and readouts on one timeline, every result attributed to its exact conditions. The ground truth AI drug discovery has always needed.
From the first well to the last frame.
Keystone™ integrates incubation, fluid handling, imaging,
and run control into a single benchtop system.
Cells stay in one environment from seeding to
final frame — every module on the same clock.
Incubation
Stable temperature, CO₂, and humidity from single-plate to multi-plate runs.
Fluidics
Programmable exchange schedules. Automated reagent delivery.
Imaging
Brightfield, fluorescence and absorbance. In-situ, non-destructive, timestamped.
Run control
Full event log. Every action timestamped, sequenced, and exportable.
Built around standard formats
96-well. The format where multi-day organoid and spheroid biology happens. 384-well in development.
A run instrument, not a culture factory — built to produce evidence, not just throughput.
Technical specifications on request — info@coherencebio.com
Help build better experimental systems.
We're building instrumentation for biology that can't afford to lose continuity. The work spans hardware, software, and application science. If this kind of problem interests you, we'd like to hear from you.
Own the integration of mechanics, fluid handling, motion control,and imaging subsystems. Make multi-day biological runs reliable,manufacturable, and testable.
Requirements: 3+ years experience in mechatronics, embedded systems,or automation hardware. End-to-end hardware delivery experience preferred.
#mechatronics #hardware #DFM #motion-control #lab-automation
Develop and maintain software that controls every action in the run —scheduling, triggering, logging, and image analysis. Make it reliable and maintainable enough that scientists never have to think about it.
Requirements: 3+ years in Python and/or C++. Hardware integrationor real-time systems experience a plus.
#Python #C++ #hardware-integration #real-time #lab-automation
Work directly with pilot labs to adapt Keystone protocols to real biological workflows. You understand what multi-day cell culture actually requires, and you can translate that into automated run configurations that produce data worth trusting.
#cell-biology #organoids #assay-development #protocol-design #lab-automation
Work directly on real deliverables alongside experienced engineers. Strong fundamentals and hands-on initiative required. Tell us your preferred area and availability.
Tell us what you’re running.
We work with a small number of labs whose protocols are limited by handoffs, timing drift, or fragile multi-day execution.
If that sounds familiar, you're who we build with.