Biology runs continuously.
Your experiments should too.
Keystone™ is a benchtop system for multi-day cell biology — integrating culture, interventions, and imaging in one uninterrupted run.
Your protocol is only as good as your worst handoff.
Every transfer introduces a variable. Every overnight gap is an uncontrolled condition. Multi-day biology is compromised not by the science, but by the infrastructure around it.
The result is data you can't trust, failures you can't attribute, and runs you have to repeat.
The learning loop breaks in execution.
A lot of expensive software was built on fragmented experimental data. We decided to fix the bottom of that stack.
New Approach Methodologies are redefining what preclinical biology requires.
Organoids mature over many days — their structure depends on environmental stability from the first hour to the last frame. Spheroids develop heterogeneous responses that only make sense when observed continuously,not reconstructed from disconnected endpoints. Keystone™ was designed for this biology. Not adapted to it.
WHAT CONTINUOUS BIOLOGY REQUIRES
Stable culture
The environment starts drifting the moment cells leave the incubator. Re-equilibration takes time cells don't have. In Keystone™, the run stays in one stable environment.
Scheduled actions
Media exchange, dosing, and staining happen automatically at defined timepoints, with every step recorded on the same run timeline.
Multimodal readout
Looking intact is not the same as being functional. Structure, phenotype, and metabolic activity should be read together — on the same timeline. Brightfield reveals morphology. Fluorescence captures phenotypic change. Absorbance verifies metabolic activity.
Brightfield reveals morphology. Fluorescence captures phenotypic change.Absorbance verifies metabolic activity — all on the same timeline.
The product is the run.
Keystone™ supports protocols where continuity is essential.
Where a gap in execution becomes a gap in the answer.
Longitudinal phenotyping
The same well, every timepoint. No plate movement between acquisitions. No re-equilibration delay.
No gap in the record.
Multi-step assay execution
Every intervention timestamped, logged, attributed to the run. Not an assumption — a record.
Drug response kinetics
Cytostatic and cytotoxic responses look identical at 72 hours. Continuous imaging resolves the kinetic difference - when the arrest began, how far it progressed, whether it recovered.
One run. One record.
Every Keystone™ run produces a traceable record: images, interventions, and readouts on one timeline, every result attributed to its exact conditions. The ground truth AI drug discovery has always needed.
From the first well to the last frame.
Keystone™ integrates incubation, fluid handling, imaging,
and run control into a single benchtop system.
Cells stay in the same environment from seeding to final acquisition.
Every module runs on the same clock.
Incubation
Stable temperature, CO₂, and humidity from single-plate to multi-plate runs.
Fluidics
Programmable exchange schedules. Automated reagent delivery.
Imaging
Brightfield, fluorescence and absorbance. In-situ, non-destructive, timestamped.
Run control
Full event log. Every action timestamped, sequenced, and exportable.
Built around standard formats
96-well. The format where multi-day organoid and spheroid biology happens. 384-well in development.
For technical specifications, contact info@coherencebio.com
Help build better experimental systems.
We're building instrumentation for biology that can't afford to lose continuity. The work spans hardware, software, and application science. If this kind of problem interests you, we'd like to hear from you.
Work directly on real deliverables alongside experienced engineers.Strong fundamentals and hands-on initiative required.Tell us your preferred area and availability.
Own the integration of mechanics, fluid handling, motion control,and imaging subsystems. Make multi-day biological runs reliable,manufacturable, and testable.
Requirements: 3+ years experience in mechatronics, embedded systems,or automation hardware. End-to-end hardware delivery experience preferred.
#mechatronics #hardware #DFM #motion-control #lab-automation
Develop and maintain software that controls every action in the run —scheduling, triggering, logging, and image analysis. Make it reliable and maintainable enough that scientists never have to think about it.Work directly with pilot labs to adapt Keystone protocols to real biological workflows. You understand what multi-day cell culture actually requires, and you can translate that into automated run configurations that produce data worth trusting.
Requirements: 3+ years in Python and/or C++. Hardware integrationor real-time systems experience a plus.
#Python #C++ #hardware-integration #real-time #lab-automation
Work directly with pilot labs to adapt Keystone protocols to real biological workflows. You understand what multi-day cell culture actually requires, and you can translate that into automated run configurations that produce data worth trusting.
#cell-biology #organoids #assay-development #protocol-design #lab-automation
Tell us what you’re running.
We're working with a small number of labs whose protocols are limited by handoffs, timing drift, or fragile multi-day execution.
If that sounds familiar, we'd like to talk.